Attacking cancer indirectly: Generating immunity against tumor vessel protein in mouse study

A novel DNA vaccine is being trialed to kill cancer, not by attacking tumor cells, but targeting the blood vessels that keep them alive. The vaccine also indirectly creates an immune response to the tumor itself, amplifying the attack by a phenomenon called epitope spreading. The team injected mice with a DNA fusion vaccine. In mouse models of three cancer types, tumor formation was delayed or prevented in mice vaccinated with the vaccine. Specifically, they found that the mouse tumors had suppr...

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